Central Ang II (Angiotensin II)-Mediated Sympathoexcitation
نویسندگان
چکیده
منابع مشابه
Circulating angiotensin II deteriorates left ventricular function with sympathoexcitation via brain angiotensin II receptor
Sympathoexcitation contributes to the progression of heart failure. Activation of brain angiotensin II type 1 receptors (AT1R) causes central sympathoexcitation. Thus, we assessed the hypothesis that the increase in circulating angiotensin II comparable to that reported in heart failure model affects cardiac function through the central sympathoexcitation via activating AT1R in the brain. In Sp...
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Despite enormous therapeutic advancements, the incidence of hypertension continues to rise and remains a medical burden of global proportions. This is likely due, in part, to the complex pathogenesis of hypertension. In addition to pathological processes in peripheral cardiovascular organs, the central nervous system (CNS) has emerged as a major culprit. The renin–angiotensin system (RAS) plays...
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ژورنال
عنوان ژورنال: Hypertension
سال: 2021
ISSN: 0194-911X,1524-4563
DOI: 10.1161/hypertensionaha.120.16002